Synthesis and Antimicrobial Activities Evaluation of Some New Thiadiazinone and Thiadiazepinone Derivatives Bearing Sulfonamide Moiety

A new series of novel functionalized 1,3,4-thiadiazin-5-ones and 1,3,4-thiadiazepin-5-ones bearing sulfonamide moieties by 1,3-dipolar cyclocondensation reaction of nitrilimines with α-mercaptoesters and mercaptosuccinic acid respectively. The structures of the newly prepared compounds were elucidated by spectral methods (IR,1H-NMR,13C-NMR and MS spectroscopy) and elemental analysis. The newly synthesized compounds were screened for their in vitro antimicrobial activity. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.

Keywords: Nitrilimines, Sulfa drugs, α-Mercaptoesters, 1,3,4-Thiadiazinone, 1,3,4-Thiadiazepinone.